A tricyclic antidepressant; binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM

Amitriptyline (hydrochloride) – 5 g

Brand:
Cayman
CAS:
549-18-8
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Amitriptyline is a first generation tricyclic antidepressant that binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively).{25873,22877} It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki =20 nM) as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).  

 

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Description

A tricyclic antidepressant; binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively); antagonist of 5-HT2A receptors (Ki =20 nM) as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively

Formal name: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride

Synonyms:  NIH 10794|Ro 4-1575

Molecular weight: 313.9

CAS: 549-18-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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