A prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors

Amiselimod (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
942398-84-7
Storage:
-20
UN-No:
Non-Hazardous - /

Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors.{33207} It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.{33207} Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.{33207}  

 

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Description

A prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors

Formal name: 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-1,3-propanediol, monohydrochloride

Synonyms:  MT-1303

Molecular weight: 413.9

CAS: 942398-84-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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