An herbicide; reversibly decreases H. vulgare root and shoot length and inhibits in vitro paclitaxel-induced tubulin polymerization in a dose-dependent manner; completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM; inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM; inhibits the growth of P. falciparum (IC50 = 3.5 μM); completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM

Amiprofos-methyl – 50 mg

Brand:
Cayman
CAS:
36001-88-4
Storage:
-20
UN-No:
Non-Hazardous - /

Amiprofos-methyl (APM) is a phosphoric amide herbicide.{38408} It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel (Item No. 10461) in a dose-dependent manner.{38408,38409} APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM.{38408} The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM.{38410} APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.{38411}  

 

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Description

An herbicide; reversibly decreases H. vulgare root and shoot length and inhibits in vitro paclitaxel-induced tubulin polymerization in a dose-dependent manner; completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM; inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM; inhibits the growth of P. falciparum (IC50 = 3.5 μM); completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM,

Formal name: N-(1-methylethyl)-phosphoramidothioic acid, O-methyl O-(4-methyl-2-nitrophenyl) ester

Synonyms:  APM|NSC 313446

Molecular weight: 304.3

CAS: 36001-88-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Pesticides|Herbicides||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Plant Biology

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