An internal standard for the quantification of amiodarone by GC- or LC-MS

Amiodarone-d4 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1216715-80-8
Storage:
-20
UN-No:
Non-Hazardous - /

Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone (Item No. 15213) by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}  

 

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SKU: 10010668 - 5 mg Category:

Description

An internal standard for the quantification of amiodarone by GC- or LC-MS

Formal name: (2-butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy-1,1,2,2-d4)-3,5-diiodophenyl)methanone, monohydrochloride

Synonyms: 

Molecular weight: 685.8

CAS: 1216715-80-8

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cardiovascular System|Heart|Arrhythmia

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