A GABA-T inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain; inhibits CBS and CSE (IC50s = 8.5 and 1.1 μM

Aminooxyacetic Acid (hydrochloride) – 1 g

Brand:
Cayman
CAS:
2921-14-4
Storage:
-20
UN-No:
Non-Hazardous - /

Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.  

 

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Description

A GABA-T inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain; inhibits CBS and CSE (IC50s = 8.5 and 1.1 μM, respectively); decreases GABA-T activity and increases GABA levels in all regions of rat brain at 100 mg/kg; decreases GABA-T activity and increases GABA in mouse brain at 13 mg/kg; inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively); exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice

Formal name: 2-(aminooxy)-acetic acid, hemihydrochloride

Synonyms:  Aminooxyacetate

Molecular weight: 109.3

CAS: 2921-14-4

Purity: ≥95%

Formulation: A crystalline solid

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