A potent

AMG 319 – 1 mg

Brand:
Cayman
CAS:
1608125-21-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform δ (PI3Kδ; IC50 = 18 nM) that less effectively targets the α, β, and γ isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively).{32332} It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells.{32332} AMG 319 is orally bioavailable and reduces inflammation in two animal models.{32332}  

 

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Description

A potent, selective inhibitor of PI3Kδ (IC50 = 18 nM); blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells; reduces inflammation in two animal models

Formal name: 7-fluoro-αS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

Synonyms: 

Molecular weight: 385.4

CAS: 1608125-21-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids|Phosphatidyl Inositol Kinases & Phosphatases

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