Description
An inhibitor of the MDM2 and p53 interaction (KD = 0.045 nM; IC50 = 0.6 nM in a cell-free binding assay); inhibits proliferation of HCT116 p53 wild-type, but not p53-/-, cells (IC50s = 10 nM and >25 µM, respectively); reduces tumor growth in an SJSA-1 osteosarcoma mouse xenograft model (ED50 = 9.1 mg/kg); induces complete regression of tumors in an SJSA-1 osteosarcoma mouse xenograft model at 75 mg/kg per day for 10 days; induces apoptosis of SJSA-1 mouse xenograft tumor cells
Formal name: (3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-[[(1-methylethyl)sulfonyl]methyl]propyl]-2-oxo-3-piperidineacetic acid
Synonyms:
Molecular weight: 568.6
CAS: 1352066-68-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53
