An inhibitor of topoisomerase II; induces double-strand breaks in SV40 DNA in the presence

Ametantrone – 5 mg

Brand:
Cayman
CAS:
64862-96-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ametantrone is an inhibitor of topoisomerase II.{46347} It induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells.{46347,46348} It also induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 µM.{46349} Ametantrone is cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 µM, respectively). It inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model when administered at a dose of 5 mg/kg, however, it increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a.{46350}  

 

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SKU: 22924 - 5 mg Category:

Description

An inhibitor of topoisomerase II; induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells; induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 µM; cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 µM, respectively); inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model at 5 mg/kg; increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a

Formal name: 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione

Synonyms:  NSC 196473|NSC 290813

Molecular weight: 412.5

CAS: 64862-96-0

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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