Description
An inhibitor of topoisomerase II; induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells; induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 µM; cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 µM, respectively); inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model at 5 mg/kg; increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a
Formal name: 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
Synonyms: NSC 196473|NSC 290813
Molecular weight: 412.5
CAS: 64862-96-0
Purity: ≥90%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase
