An antiviral inhibitor of HSV-1 helicase-primase complex activity; inhibits recombinant HSV-1 helicase (IC50 = 0.078 μM); inhibits recombinant HSV-1 primase at ≥0.03 μM; inhibits replication of VZV

Amenamevir – 1 mg

Brand:
Cayman
CAS:
841301-32-4
Storage:
-20
UN-No:
Non-Hazardous - /

Amenamevir is an antiviral inhibitor of herpes simplex virus 1 (HSV-1) helicase-primase complex activity.{35890} It inhibits recombinant HSV-1 helicase with an IC50 value of 0.078 μM and recombinant HSV-1 primase when used at concentrations greater than or equal to 0.03 μM. Amenamevir inhibits replication of varicella-zoster virus (VZV), HSV-1, and HSV-2 in human embryonic fibroblast (HEF) cells (EC50s = 0.047, 0.036, and 0.028 μM, respectively) and is not cytotoxic to HEF cells with a 50% cytotoxic concentration (CC50) of greater than 30 μM. Amenamevir also inhibits replication of clinical VZV isolates in HEF cells (EC50s = 0.038-0.10 μM). In vivo, it increases survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection (ED50 = 1.9 mg/kg twice per day).  

 

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Description

An antiviral inhibitor of HSV-1 helicase-primase complex activity; inhibits recombinant HSV-1 helicase (IC50 = 0.078 μM); inhibits recombinant HSV-1 primase at ≥0.03 μM; inhibits replication of VZV, HSV-1, and HSV-2 in HEF cells (EC50s = 0.047, 0.036, and 0.028 μM, respectively); not cytotoxic to HEF cells (CC50 = >30 μM); inhibits replication of clinal VZV isolates in HEF cells (EC50s = 0.038-0.10 μM); increases survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection (ED50 = 1.9 mg/kg twice per day)

Formal name: N-(2,6-dimethylphenyl)tetrahydro-N-[2-[[4-(1,2,4-oxadiazol-3-yl)phenyl]amino]-2-oxoethyl]-2H-thiopyran-4-carboxamide, 1,1-dioxide

Synonyms:  ASP2151

Molecular weight: 482.6

CAS: 841301-32-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals|Helicase-primase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Chicken Pox & Shingles||Research Area|Infectious Disease|Viral Diseases|HSV

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