A CB1 receptor neutral antagonist (Ki = 178 nM; Kb = 66.6 nM); no activity at CB2 receptors at concentrations up to 10 µM; an antagonist of GPR18 (IC50 = 3.74 µM); has vasodilatory activity

Amauromine – 1 mg

Brand:
Cayman
CAS:
88360-87-6
Storage:
-20
UN-No:
Non-Hazardous - /

Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1 that is selective for CB1 (Ki = 178 nM; Kb = 66.6 nM) over CB2, with no activity at CB2 receptors at concentrations up to 10 µM.{36266} It is also an antagonist of GPR18 (IC50 = 3.74 µM).{36265} Amauromine has vasodilatory activity.{36267}  

 

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SKU: 23886 - 1 mg Category:

Description

A CB1 receptor neutral antagonist (Ki = 178 nM; Kb = 66.6 nM); no activity at CB2 receptors at concentrations up to 10 µM; an antagonist of GPR18 (IC50 = 3.74 µM); has vasodilatory activity

Formal name: (5aS,7aS,8aR,13aS,15aS,16aR)-8a,16a-bis(1,1-dimethyl-2-propen-1-yl)-5a,8,8a,13,13a,15a,16,16a-octahydro-pyrazino[1”,2”:1,5;4”,5”:1′,5′]dipyrrolo[2,3-b:2′,3′-b’]diindole-7,15(5H,7aH)-dione

Synonyms: 

Molecular weight: 508.7

CAS: 88360-87-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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