A secoiridoid glycoside with diverse biological activities; inhibits the growth of SNU-16 cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis at 50 µM; reduces tumor growth in a SNU-16 nude mouse xenograft model in a dose-dependent manner; reduces plasma glucose levels in rat model of diabetes induced by STZ in a dose-dependent manner; reverses the STZ-induced increase in soleus muscle levels of Glut4 at 0.5 mg/kg; reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner

Amarogentin – 25 mg

Brand:
Cayman
CAS:
21018-84-8
Storage:
-20
UN-No:
Non-Hazardous - /

Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties.{43265,43266,43267} It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis when used at a concentration of 50 µM.{43266} Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg.{43267} Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.{43265}  

 

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Description

A secoiridoid glycoside with diverse biological activities; inhibits the growth of SNU-16 cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis at 50 µM; reduces tumor growth in a SNU-16 nude mouse xenograft model in a dose-dependent manner; reduces plasma glucose levels in rat model of diabetes induced by STZ in a dose-dependent manner; reverses the STZ-induced increase in soleus muscle levels of Glut4 at 0.5 mg/kg; reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner

Formal name: 5-ethenyl-4,4aS,5R,6S-tetrahydro-6-[[2-O-[(3,3′,5-trihydroxy[1,1′-biphenyl]-2-yl)carbonyl]-β-D-glucopyranosyl]oxy]-1H,3H-pyrano[3,4-c]pyran-1-one

Synonyms: 

Molecular weight: 586.5

CAS: 21018-84-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis

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