Immunogen: Peptide from the N-terminal region of human p504s • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) p504s • Applications: IHC

AMACR (N-Term) Rabbit Monoclonal Antibody – 100 µl

Brand:
Cayman
Storage:

α-methylacyl-Coenzyme A (α-methylacyl-CoA) racemase (AMACR), is an enzyme involved in the metabolism of branched chain fatty acids and 2-arylpropanoic acids (2-APAs), such as ibuprofen (Item No. 70280).{60129} It is expressed in most human tissues and is localized to peroxisomes and mitochondria.{60129,60130} AMACR converts R-2-methyl fatty acids to S-2-methylacyl-CoA esters via an epimerization reaction prior to their degradation by β-oxidation.{60129} AMACR is overexpressed in localized and metastatic prostate cancer, as well as in a variety of other cancers.{60131} AMACR has been found selectively in patient-derived prostate cancer tumor tissue compared to non-cancer prostate tissue, and has been used as a biomarker of the disease.{60132} Mutations in AMACR resulting in reduced enzyme activity lead to the accumulation of R-2-methyl fatty acids and are associated with neurological and peroxisomal disorders.{60133} Cayman’s AMACR (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.  

 

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SKU: 32274 - 100 µl Category:

Description

Immunogen: Peptide from the N-terminal region of human p504s • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) p504s • Applications: IHC, WB

Synonyms: 2-arylpropionyl-CoA Epimerase|2-R-Ibuprofenyl racemase|P504S|α-methylacyl-CoA

Immunogen: Peptide from the N-terminal region of human p504s

Formulation: 100 µl of protein A-affinity purified antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Fatty Acids|Degradation||Research Area|Neuroscience

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