A retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM); induces human promyelocytic leukemia HL-60 cell differentiation (ED50 = 0.79 nM) and exhibits antiproliferative effects against acute promyelocytic leukemia and other malignant cells

AM80 – 10 mg

Brand:
Cayman
CAS:
94497-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM).{24736} It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.{25644,24736} AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM.{23266,25644} It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.{25644}  

 

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SKU: 71770 - 10 mg Category:

Description

A retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM); induces human promyelocytic leukemia HL-60 cell differentiation (ED50 = 0.79 nM) and exhibits antiproliferative effects against acute promyelocytic leukemia and other malignant cells

Formal name: 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-benzoic acid

Synonyms:  Amnolake|NSC 608000|Retinobenzoic Acid|Tamibarotene

Molecular weight: 351.4

CAS: 94497-51-5

Purity: ≥98%

Formulation: A crystalline solid

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