A retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM); used in combination with the GSK3β inhibitor CHIR99021 to induce differentiation of human induced pluripotent stem cells

AM580 – 10 mg

Brand:
Cayman
CAS:
102121-60-8
Storage:
-20
UN-No:
Non-Hazardous - /

AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM).{24736} It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.{24736,18516,20156} AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Item No. 13122) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.{25645} It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.{25647,25646}  

 

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Description

A retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM); used in combination with the GSK3β inhibitor CHIR99021 to induce differentiation of human induced pluripotent stem cells

Formal name: 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-benzoic acid

Synonyms:  CD336|NSC 608001|Ro 40-6055

Molecular weight: 351.4

CAS: 102121-60-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Stem Cell Research|Differentiation

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