A CB1-selective neutral antagonist (Ki = 0.89 nM); reduces food intake in rats

AM4113 – 5 mg

Brand:
Cayman
CAS:
614726-85-1
Storage:
-20
UN-No:
Non-Hazardous - /

AM4113 is a cannabinoid receptor 1 (CB1)-selective neutral antagonist that binds to CB1 and CB2 with Ki values of 0.89 and 92 nM, respectively.{32595} In rats, it has been shown to reduce food intake and food-reinforced behavior, such as time spent feeding, thereby reducing weight gain without inducing nausea.{32594} This compound has also been used to study the abuse-related effects of nicotine, as well as the effects of nicotine on anxiety and depressive-like behavior in rats.{32593}  

 

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Description

A CB1-selective neutral antagonist (Ki = 0.89 nM); reduces food intake in rats

Formal name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Synonyms: 

Molecular weight: 380.7

CAS: 614726-85-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Cannabinoid Research

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