An analog of AEA that potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons; selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis; inhibits the transport of AEA with an IC50 value of 1 µM in rat neurons and 5 µM in rat astrocytes; enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg in in vivo models

AM404 – 10 mg

Brand:
Cayman
CAS:
183718-77-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

AM404 is an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons. AM404 selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis. It inhibits the transport of AEA with an IC50 of 1 µM in rat neurons and 5 µM in rat astrocytes. In in vivo models, AM404 enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg.{4894}  

 

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SKU: 90060 - 10 mg Category:

Description

An analog of AEA that potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons; selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis; inhibits the transport of AEA with an IC50 value of 1 µM in rat neurons and 5 µM in rat astrocytes; enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg in in vivo models

Formal name: N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetrenamide

Synonyms:  4-HPA|N-(4-hydroxyphenyl)-Arachidonoyl Amide

Molecular weight: 395.6

CAS: 183718-77-6

Purity: ≥98%

Formulation: A solution in ethanol

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