A potent and selective CB1 receptor antagonist/inverse agonist (Ki = 12 and 4

AM281 – 10 mg

Brand:
Cayman
CAS:
202463-68-1
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively).{13046,21749} Structurally, it is an analog of the CB1 inverse agonist rimonabant (Item No. 9000484).{21749} It has no effect on the vanilloid TRPV1 receptor.{12165} AM281 has been used to evaluate the potential effects of compounds at CB1.{13244,21496} It has also been used to study the membrane localization and cycling of CB1.{13567}  

 

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SKU: 10006972 - 10 mg Category:

Description

A potent and selective CB1 receptor antagonist/inverse agonist (Ki = 12 and 4,200 nM for CB1 and CB2, respectively)

Formal name: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide

Synonyms: 

Molecular weight: 557.2

CAS: 202463-68-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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