A selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis; is the structurally “reversed” isomer of AM404; blocks the uptake of tritiated AEA with an EC50 value of about 1.5 µM in mouse cortical neurons

AM1172 – 50 mg

Brand:
Cayman
CAS:
251908-92-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity.{10254} This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.{10647} AM1172 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis.{11852} Structurally, AM1172 is the “reversed” isomer of AM404, constructed using arachidonyl amine; this may account for its metabolic stability. In mouse cortical neurons, AM1172 blocked the uptake of tritiated AEA with an EC50 of about 1.5 µM.{11852}  

 

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SKU: 10005223 - 50 mg Category:

Description

A selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis; is the structurally “reversed” isomer of AM404; blocks the uptake of tritiated AEA with an EC50 value of about 1.5 µM in mouse cortical neurons

Formal name: N-5Z,8Z,11Z,14Z-eicosatetraenyl-4-hydroxy-benzamide

Synonyms: 

Molecular weight: 409.6

CAS: 251908-92-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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