An isothiocyanate with diverse biological activities; active against a variety of bacteria and the plant pathogenic fungus A. niger; directly inhibits PAH-induced CYP1A1 and CYP1A2 activity in MCF-7 cells at 0.5-2.5 µM; inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM

Alyssin – 1 mg

Brand:
Cayman
CAS:
646-23-1
Storage:
-20
UN-No:
Non-Hazardous - /

Alyssin is an isothiocyanate that has been found in W. japonica and has diverse biological activities, including antibacterial, fungicidal, CYP inhibitory, and antiproliferative properties.{57313,57314,57315} It is active against the bacteria B. subtilis, methicillin-sensitive S. aureus, methicillin-resistant S. aureus (MRSA), and E. coli, and the plant pathogenic fungus A. niger.{57313} Alyssin (0.5-2.5 µM) directly inhibits activity of the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 induced by the polycyclic aromatic hydrocarbons (PAHs) anthracene and dibenzo[a,h]anthracene in MCF-7 breast cancer cells.{57314} It inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM, respectively).{31409}  

 

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SKU: 31513 - 1 mg Category:

Description

An isothiocyanate with diverse biological activities; active against a variety of bacteria and the plant pathogenic fungus A. niger; directly inhibits PAH-induced CYP1A1 and CYP1A2 activity in MCF-7 cells at 0.5-2.5 µM; inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM, respectively)

Formal name: 1-isothiocyanato-5-(methylsulfinyl)-pentane

Synonyms:  5-Methylsulfinylpentyl isothiocyanate|5-Methylsulfinylpentyl ITC

Molecular weight: 191.3

CAS: 646-23-1

Purity: ≥95%

Formulation: A neat oil

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