An antineoplastic agent and GPX4 inhibitor; induces cytotoxicity in an ovarian cancer cell line at 10 µg/ml; reduces colony survival in A204 human rhabdomyosarcoma cells in an NADP-dependent manner in the presence of an S-9 hepatic activating mixture at 100 µg/ml; reduces tumor growth in a mouse model of M5076 murine reticulum cell sarcoma at 150 mg/kg; inhibits GPX4 and induces lipid-ROS accumulation at 0.5 mM; acts as a chemosterilant in houseflies

Altretamine – 100 mg

Brand:
Cayman
CAS:
645-05-6
Storage:
4
UN-No:
Non-Hazardous - /

Altretamine is an antineoplastic agent with antiproliferative activity.{41191} It induces cytotoxicity in an ovarian cancer cell line when used at a concentration of 10 μg/ml, with radiolabeled thymidine uptake equal to 102 and 75% of controls after 48 and 120 hours, respectively.{41189} Altretamine (100 μg/ml) reduces colony survival in A204 human rhabdomyosarcoma cells in an NADP-dependent manner in the presence of an S-9 hepatic activating mixture.{41190} In vivo, altretamine (150 mg/kg) reduces tumor growth in a mouse model of M5076 murine reticulum cell sarcoma.{41191} Altretamine (0.5 mM) inhibits glutathione peroxidase 4 (GPX4) and induces accumulation of lipid-reactive oxygen species (ROS) in U-2932 cells without depleting glutathione (GSH) levels, suggesting it is a class II ferroptosis-inducing compound (FIN).{47408} It also acts as a chemosterilant in houseflies, preventing hatching and pupation in male and female houseflies when used at a concentration of 0.05%.{41192} Formulations of altretamine have been used in the treatment of various cancers.  

 

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Description

An antineoplastic agent and GPX4 inhibitor; induces cytotoxicity in an ovarian cancer cell line at 10 µg/ml; reduces colony survival in A204 human rhabdomyosarcoma cells in an NADP-dependent manner in the presence of an S-9 hepatic activating mixture at 100 µg/ml; reduces tumor growth in a mouse model of M5076 murine reticulum cell sarcoma at 150 mg/kg; inhibits GPX4 and induces lipid-ROS accumulation at 0.5 mM; acts as a chemosterilant in houseflies, preventing hatching and pupation in male and female houseflies at 0.05%

Formal name: N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine

Synonyms:  2,4,6-Tris(dimethylamino)-1,3,5-triazine|Hexamethylmelamine|HMM|NSC 13875

Molecular weight: 210.3

CAS: 645-05-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Toxicology|Environmental

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