A mycotoxin from A. brassicae; a common contaminant in cereal grains such as wheat

Alternariol monomethyl ether – 1 mg

Brand:
Cayman
CAS:
23452-05-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells).{38070,38071} It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM).{33238,38072} AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.{38071}  

 

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SKU: 11307 - 1 mg Category:

Description

A mycotoxin from A. brassicae; a common contaminant in cereal grains such as wheat, barley, and sorghum; cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides) and mammalian cells (IC50 = 120 μM in HCT116 cells); inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively; selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM); provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis,

Formal name: 3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one

Synonyms:  AME|NSC 638262

Molecular weight: 272.3

CAS: 23452-05-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology

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