An aldose reductase inhibitor (IC50 = 1.5 µM for rat lens enzyme); selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC50 = 58 µM); reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations; increases plasma insulin levels in fasted anesthetized rats at 0.75 mmol/kg; inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes; inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED50s = 90 and 330 mg/kg

Alrestatin – 5 mg

Brand:
Cayman
CAS:
51411-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

Alrestatin is an inhibitor of aldose reductase (IC50 = 1.5 µM for rat lens enzyme).{52459} It is selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC50 = 58 µM). Alrestatin reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations.{52458} In vivo, alrestatin (0.75 mmol/kg) increases plasma insulin levels in fasted anesthetized rats. Alrestatin inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes.{52460} It also inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED50s = 90 and 330 mg/kg, respectively).  

 

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SKU: 29888 - 5 mg Category:

Description

An aldose reductase inhibitor (IC50 = 1.5 µM for rat lens enzyme); selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC50 = 58 µM); reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations; increases plasma insulin levels in fasted anesthetized rats at 0.75 mmol/kg; inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes; inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED50s = 90 and 330 mg/kg, respectively)

Formal name: 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid

Synonyms:  AY-22284|NSC 299132

Molecular weight: 255.2

CAS: 51411-04-2

Purity: ≥98%

Formulation: A crystalline solid

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