An alkaloid with diverse biological activities; inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM

Aloperine – 1 g

Brand:
Cayman
CAS:
56293-29-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.{39317,39318,39319,39320} It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively) at concentrations well below the cytotoxic concentration (CC50) of >86.5 μM in vitro.{39317} Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC50 values of 40, 270, and 360 μM, respectively.{39318} Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension.{39319} Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis.{39320}  

 

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Description

An alkaloid with diverse biological activities; inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively); inhibits the growth of HL-60, U937, and K562 leukemia cell lines (IC50s = 40, 270, and 360 μM, respectively); reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension; reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis,

Formal name: 1,3,4,6R,6aR,7,8,9,10,12,13R,13aS-dodecahydro-6,13-methano-2H-dipyrido[1,2-a:3′,2′-e]azocine

Synonyms: 

Molecular weight: 232.4

CAS: 56293-29-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Immunology & Inflammation|Allergy||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species

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