Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine

Aloe-emodin – 10 mg

Brand:
Cayman
CAS:
481-72-1
Storage:
-20
UN-No:
Non-Hazardous - /

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}  

 

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SKU: 11677 - 10 mg Category:

Description

Functions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle; also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells

Formal name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione

Synonyms:  3-Hydroxymethylchrysazine|NSC 38628|Rhabarberone

Molecular weight: 270.2

CAS: 481-72-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Anthraquinones||Product Type|Biochemicals|Natural Products|Phytosterols||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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