An orexin 1 and orexin 2 receptor antagonist (Kis = 4.7 and 0.9 nM

Almorexant (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
913358-93-7
Storage:
-20
UN-No:
Non-Hazardous - /

Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}  

 

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Description

An orexin 1 and orexin 2 receptor antagonist (Kis = 4.7 and 0.9 nM, respectively); decreases the latency to persistent NREM and REM sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg; does not impair spatial learning and memory in the Morris water maze at 300 mg/kg

Formal name: (αR,1S)-3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide, monohydrochloride

Synonyms:  ACT 078573

Molecular weight: 549

CAS: 913358-93-7

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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