A pyrethroid insecticide and modulator of NaVs; delays channel deactivation in cockroach giant axons at 1 μM; 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes; decreases egg production by and is lethal to mosquitos (LC50 = 0.01%); induces production of ROS

Allethrin – 100 mg

Brand:
Cayman
CAS:
584-79-2
Storage:
-20
UN-No:
De Minimis - 3082 / 9

Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV).{39796} It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes.{36375} It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%).{39797} Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells.{39798} In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.{39799}  

 

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Description

A pyrethroid insecticide and modulator of NaVs; delays channel deactivation in cockroach giant axons at 1 μM; 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes; decreases egg production by and is lethal to mosquitos (LC50 = 0.01%); induces production of ROS, lipid peroxidation, and apoptosis in rat primary Leydig cells; increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice,

Formal name: 2,2-dimethyl-3-(2-methyl-1-propen-1-yl)-cyclopropanecarboxylic acid, 2-methyl-4-oxo-3-(2-propen-1-yl)-2-cyclopenten-1-yl ester

Synonyms:  NSC 11782|RU 27436

Molecular weight: 302.4

CAS: 584-79-2

Purity: ≥95%

Formulation: An oil

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Neuroscience||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental

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