An agonist of RAR isoforms (EC50s = 77

all-trans-5,6-epoxy Retinoic Acid – 500 µg

Brand:
Cayman
CAS:
13100-69-1
Storage:
-20
UN-No:
Non-Hazardous - /

all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).{34779} 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of all-trans retinoic acid (Item No. 11017), which is a metabolite of vitamin A.{34778}  

 

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Description

An agonist of RAR isoforms (EC50s = 77, 35, and 4 nM for RARα, RARα, and RARγ, respectively); induces growth arrest of MCF-7 and NB4 cells in vitro; a natural metabolite of vitamin A

Formal name: 5,6-epoxy-5,6-dihydro-retinoic acid

Synonyms:  5,6-epoxy RA|5,6-epoxy-atRA

Molecular weight: 316.4

CAS: 13100-69-1

Purity: ≥96%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs

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