Description
A naphthoquinone with diverse biological activities; enantiomer of shikonin; selectively inhibits tumor-specific PKM2 (IC50 = 0.3 μM) over PKM1 and PKL; inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s = 2.38 and 4.53 μM, respectively); halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 μM; increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 μM; active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively); scavenges DPPH radicals in a cell-free assay (EC50 = 22 ppm)
Formal name: 5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
Synonyms: (–)-Alkannin|NSC 94524
Molecular weight: 288.3
CAS: 517-88-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Natural Products|Naphthoquinones||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cellular Chaperones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
