A dopamine D2 receptor antagonist; selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101

Alizapride (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
59338-87-3
Storage:
-20
UN-No:
Non-Hazardous - /

Alizapride is a dopamine D2 receptor antagonist.{45087,45088} It selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively).{45087} It reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rats.{45088} Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.  

 

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SKU: 25645 - 100 mg Category:

Description

A dopamine D2 receptor antagonist; selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively); reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rat

Formal name: 6-methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide, monohydrochloride

Synonyms: 

Molecular weight: 351.8

CAS: 59338-87-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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