An inhibitor of mutant EGFRs; selective for EGFRL858R

Alflutinib (mesylate) – 5 mg

Brand:
Cayman
CAS:
2130958-55-1
Storage:
-20
UN-No:
Non-Hazardous - /

Aflutinib is an inhibitor of mutant EGFRs.{54445} It is selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.  

 

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SKU: 31473 - 5 mg Category:

Description

An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg

Formal name: N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide, monomethanesulfonate

Synonyms:  AST2818

Molecular weight: 664.7

CAS: 2130958-55-1

Purity: ≥98%

Formulation: A crystalline solid

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