A selective ALDH2 agonist; enhances wild-type ALDH2*1 and East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-

Alda-1 – 50 mg

Brand:
Cayman
CAS:
349438-38-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist.{39173} This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively).{39172} Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.  

 

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Description

A selective ALDH2 agonist; enhances wild-type ALDH2*1 and East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM); has no effect on alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5; protects against ex vivo ischemic tissue damage to excised rat hearts; reduces infarct size in anesthetized live rats,

Formal name: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-benzamide

Synonyms: 

Molecular weight: 324.2

CAS: 349438-38-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction

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