A benzimidazole anthelmintic; active against a variety of helminths

Albendazole – 10 g

Brand:
Cayman
CAS:
54965-21-8
Storage:
-20
UN-No:
Non-Hazardous - /

Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms.{41686} It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally.{41687} Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively).{41688} Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.  

 

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SKU: 23705 - 10 g Category:

Description

A benzimidazole anthelmintic; active against a variety of helminths, including liver flukes, tapeworms, and roundworms; eliminates Trichostrongylus in the fourth stomach of cattle and sheep (2.5-10 mg/kg) as well as other species; protects mice against lethal infection with A. suum larvae (0.05% in the diet); inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis; inhibits peritoneal tumor growth in an HT-29 mouse xenograft model (150 mg/kg, i.p.); inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively)

Formal name: N-[6-(propylthio)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester

Synonyms:  NSC 220008|SKF 62979

Molecular weight: 265.3

CAS: 54965-21-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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