A peptide agonist of GnRH; binds to GnRHR (Kd = 0.2 nM); decreases GnRH and GnRHR expression in the preoptic area and pMBH

Alarelin (acetate) – 100 mg

Brand:
Cayman
CAS:
79561-22-1
Storage:
-20
UN-No:
Non-Hazardous - /

Alarelin is a peptide agonist of gonadotropin-releasing hormone (GnRH).{36464} It binds to the GnRH receptor (GnRHR) with a Kd value of 0.2 nM. Alarelin (6 ng, i.c.v.) decreases the expression of GnRH in the preoptic area and GnRHR in the posterior mediobasal hypothalamus (pMBH) of ovariectomized estradiol-treated rats, indicating an ultrashort negative feedback loop on GnRH and GnRHR gene expression.{57077} It induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats.{57078} Alarelin reduces tumor growth in an HEC-1-B human endometrial carcinoma mouse xenograft model when administered at doses of 20, 40, and 80 µg/kg.{57079}  

 

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Description

A peptide agonist of GnRH; binds to GnRHR (Kd = 0.2 nM); decreases GnRH and GnRHR expression in the preoptic area and pMBH, respectively, of ovariectomized estradiol-treated rats at 6 ng, i.c.v., indicating an ultrashort negative feedback loop; induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats; reduces tumor growth in an HEC-1-B mouse xenograft model at 20, 40, and 80 µg/mg

Formal name: 6-D-alanine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), diacetate

Synonyms:  [D-Ala6, des-Gly10]GnRH-ethylamide|des-Gly GnRH|pGlu-HWSYALRP-NHEt

Molecular weight: 1,287.40

CAS: 79561-22-1

Purity: ≥98%

Formulation: A crystalline solid

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