A potent 5-HT2 receptor agonist with ocular hypotensive activity; binds to the human and rat 5-HT2 receptors in cerebral cortex homogenates with IC50 values of 1.5 and 0.77 nM

AL 34662 – 50 mg

Brand:
Cayman
CAS:
210580-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated via at least six major 5-HT receptor subtypes, including 5-HT2 AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. It binds to the human and rat 5-HT2 receptors in cerebral cortex homogenates with IC50 values of 1.5 and 0.77 nM, respectively.{15497} AL 34662 binds to the recombinant human 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 14.5, 8.1, and 3 nM, respectively. In ocular hypertensive cynomolgus monkey eyes, AL 34662 lowered intraocular pressure (IOP) 25% at a dose of 100 µg and 33% at 300 µg (six hours post dose) with minimal side effects.{15497}  

 

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Description

A potent 5-HT2 receptor agonist with ocular hypotensive activity; binds to the human and rat 5-HT2 receptors in cerebral cortex homogenates with IC50 values of 1.5 and 0.77 nM, respectively; lowers IOP 25 % at a dose of 100 µg and 33 % at 300 µg at six hours post dose

Formal name: 1-[(2S)-2-aminopropyl]-1H-indazol-6-ol

Synonyms:  AL 34497

Molecular weight: 191.2

CAS: 210580-75-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Ophthalmology

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