An inhibitor of Akt activation; inhibits Akt-mediated nuclear export of FOXO1a (IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner; inhibits replication of PIV5 in HeLa cells (IC50 = 520 nM); reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of ROS

Akt Inhibitor IV – 5 mg

Brand:
Cayman
CAS:
681281-88-9
Storage:
-20
UN-No:
Non-Hazardous - /

Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner.{36268} Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM).{36269} It also reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).{36270}  

 

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Description

An inhibitor of Akt activation; inhibits Akt-mediated nuclear export of FOXO1a (IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner; inhibits replication of PIV5 in HeLa cells (IC50 = 520 nM); reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of ROS

Formal name: 6-(2-benzothiazolyl)-1-ethyl-2-[2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium, monoiodide

Synonyms: 

Molecular weight: 614.6

CAS: 681281-88-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Cycle|G2/S||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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