A SIRT2 inhibitor (IC50 = 12.5 µM); induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1; decreases total cholesterol levels in Neuro2a and primary rat striatal neurons

AK-1 – 25 mg

Brand:
Cayman
CAS:
330461-64-8
Storage:
-20
UN-No:
Non-Hazardous - /

AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50 = 12.5 µM).{21802} It induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.{17495} AK-1 (5 µM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures.{21802} It increases ubiquitination of hypoxia-inducible factor-1α (HIF-1α) in A549 cells and decreases HIF-1α levels in A549, HeLa, HEK293, and HEK293T cells under hypoxic conditions when used at a concentration of 10 µM.{46587} AK-1 (1 and 10 µM in the diet) decreases the loss of rhabdomeres in the ommatidium in the UAS-Httex1p-Q93 transgenic Drosophila model of Huntington’s disease.{46588} Dietary administration of AK-1 (500 and 1,000 µM) prevents dopaminergic neuronal cell death in the dorsomedial cluster in the elav-GAL4 transgenic Drosophila model of Parkinson’s disease.{17495}  

 

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Description

A SIRT2 inhibitor (IC50 = 12.5 µM); induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1; decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures at 5 µM; increases ubiquitination of HIF-1α in A549 cells and decreases HIF-1α levels in A549, HeLa, HEK293, and HEK293T cells under hypoxic conditions at 10 µM; decreases the loss of rhabdomeres in the ommatidium in the UAS-Httex1p-Q93 transgenic Drosophila model of Huntington’s disease at 1 and 10 µM in the diet; prevents dopaminergic neuronal cell death in the dorsomedial cluster in the elav-GAL4 transgenic Drosophila model of Parkinson’s disease at 500 and 1,000 µM in the diet

Formal name: 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide

Synonyms: 

Molecular weight: 403.5

CAS: 330461-64-8

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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