A quassinoid with diverse biological activities; active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml

Ailanthone – 5 mg

Brand:
Cayman
CAS:
981-15-7
Storage:
-20
UN-No:
- 2811 / 6.1

Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities.{47771,47772,47773} It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively).{47771} Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM.{47772} It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM.{47773} Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.  

 

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Description

A quassinoid with diverse biological activities; active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively); inhibits radish seed germination by 88% when used at a concentration of 1 mM; inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 cells at 0.1 μM; reduces tumor volume in 22Rv1, LNCaP, and VCaP CRPC mouse xenograft models at 2 mg/kg

Formal name: (1β,11β,12α)-11,20-epoxy-1,11,12-trihydroxy-picrasa-3,13(21)-diene-2,16-dione

Synonyms:  Δ13-Dehydrochaparrinone

Molecular weight: 376.4

CAS: 981-15-7

Purity: ≥98%

Formulation: A crystalline solid

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