An internal standard for the quantification of AHU377 by GC- or LC-MS

AHU377-d4 – 500 µg

Brand:
Cayman
CAS:
1884269-07-1
Storage:
-20
UN-No:
Non-Hazardous - /

AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 (Item No. 21473) by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.  

 

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SKU: 25264 - 500 µg Category:

Description

An internal standard for the quantification of AHU377 by GC- or LC-MS,

Formal name: (αR,γS)-γ-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-α-methyl-[1,1′-biphenyl]-4-pentanoic acid, α-ethyl ester

Synonyms:  Sacubitril-d4

Molecular weight: 415.5

CAS: 1884269-07-1

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A film

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease

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