An iridoid glycoside with diverse biological activities; inhibits COX-2 (IC50 = 0.026 mg/ml); inhibits P-gp ATPase activity from 5-100 μM; induces proliferation of MCF-7 breast cancer cells from 0.1-10 μM; reduces acetic acid-induced writhing in mice at 50 mg/kg; suppresses production of pro-inflammatory mediators and T cell mediated cytokines in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats

Agnuside – 1 mg

Brand:
Cayman
CAS:
11027-63-7
Storage:
-20
UN-No:
Non-Hazardous - /

Agnuside is an iridoid glycoside originally isolated from V. rotundifolia fruit that has diverse biological activities.{42077,42078,42079,42080} It inhibits COX-2 with an IC50 value of 0.026 mg/ml but exhibits less than 10% inhibition of COX-1 at this concentration.{42077} It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.{25373} Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant (ICI 182780; Item No. 10011269).{42078} In vivo, agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.{42079} It also suppresses production of the pro-inflammatory mediators prostaglandin E2 (PGE2) and leukotriene B4 (LTB4; Item No. 20110) and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.{42080}  

 

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SKU: 24971 - 1 mg Category:

Description

An iridoid glycoside with diverse biological activities; inhibits COX-2 (IC50 = 0.026 mg/ml); inhibits P-gp ATPase activity from 5-100 μM; induces proliferation of MCF-7 breast cancer cells from 0.1-10 μM; reduces acetic acid-induced writhing in mice at 50 mg/kg; suppresses production of pro-inflammatory mediators and T cell mediated cytokines in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats ,

Formal name: 1S,4aR,5S,7aS-tetrahydro-5-hydroxy-7-[[(4-hydroxybenzoyl)oxy]methyl]cyclopenta[c]pyran-1-yl, β-D-glucopyranoside

Synonyms: 

Molecular weight: 466.4

CAS: 11027-63-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Pain Research

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