A tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl

AG957 – 5 mg

Brand:
Cayman
CAS:
140674-76-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.{15153} AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins).{29184} It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM).{29184} As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line.{29187,29186} AG957 is also used to study signaling through c-Abl.{29185}  

 

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Description

A tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl, as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins); also inhibits EGFR (IC50 = 0.25 µM)

Formal name: 4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester

Synonyms:  NSC 654705|Tyrphostin AG957

Molecular weight: 273.3

CAS: 140674-76-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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