An inhibitor of EGFR kinase with an IC50 value of 3 nM

AG-1478 – 25 mg

Brand:
Cayman
CAS:
153436-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTK. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor receptor (EGFR) kinase and block EGFR-dependent cell proliferation. AG-1478 is an inhibitor of EGFR kinase with an IC50 value of 3 nM.{15153} Due to its potency and selectivity, AG-1478 has been used in a broad range of studies. It reversibly inhibits rat brain Kv1.5 potassium channels (IC50 = 9.8 µM) independent of protein tyrosine kinase (PTK) activity.{15592} AG-1478 also inhibits the growth of leiomyoma and myometrium cell cultures with IC50 values of 5.6 and 5.7 µM, respectively.{15593} This inhibitor suppresses MAP kinase activation and strongly inhibits induction of fos gene expression and DNA synthesis.{15591}  

 

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SKU: 10010244 - 25 mg Category:

Description

An inhibitor of EGFR kinase with an IC50 value of 3 nM

Formal name: N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamine

Synonyms:  NSC 693255|Tyrphostin AG-1478

Molecular weight: 315.8

CAS: 153436-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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