A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 µM); inhibits PDGF-stimulated DNA synthesis (IC50 = 2.5 µM) without affecting activity of the EGF receptor

AG-1295 – 10 mg

Brand:
Cayman
CAS:
71897-07-9
Storage:
-20
UN-No:
Non-Hazardous - /

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas.{15153} AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 µM).{15594} It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 µM without affecting activity of the EGF receptor.{15594}  

 

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Description

A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 µM); inhibits PDGF-stimulated DNA synthesis (IC50 = 2.5 µM) without affecting activity of the EGF receptor

Formal name: 6,7-dimethyl-2-phenyl-quinoxaline

Synonyms:  NSC 380341|Tyrphostin AG-1295

Molecular weight: 234.3

CAS: 71897-07-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area

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