An orally available inhibitor of mutant IDH1 that may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells

AG-120 – 5 mg

Brand:
Cayman
CAS:
1448347-49-6
Storage:
-20
UN-No:
Non-Hazardous - /

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate.{32361} AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.{32361}  

 

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Description

An orally available inhibitor of mutant IDH1 that may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells

Formal name: (2S)-1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-glycinamide

Synonyms:  Invosidenib

Molecular weight: 583

CAS: 1448347-49-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Mitochondrial Biology

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