An inducer of Aβ42; selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells from 1 to 100 mM; increases hippocampal Aβ42 content

Aftin-4 – 10 mg

Brand:
Cayman
CAS:
866893-90-5
Storage:
-20
UN-No:
Non-Hazardous - /

Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42).{45169} It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice.{45170} It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.  

 

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Description

An inducer of Aβ42; selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells from 1 to 100 mM; increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice from 3-20 nmol/animal; induces spatial working and spatial reference memory deficits in mice

Formal name: 2R-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol

Synonyms: 

Molecular weight: 368.5

CAS: 866893-90-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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