A multi-targeted anxiolytic drug with neuroprotective activities; binds to the sigma-1

Afobazole (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
173352-39-1
Storage:
-20
UN-No:
Non-Hazardous - /

Afobazole is a multi-targeted anxiolytic drug with neuroprotective activities.{46420,46421} It binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as monoamine oxidase A (MAO-A; Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay).{46420} Afobazole (5 mg/kg) decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice.{46422} It decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 0.3 and 3 mg/kg.{46421}  

 

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Description

A multi-targeted anxiolytic drug with neuroprotective activities; binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as MAO-A (Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay); decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice at 5 mg/kg; decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by MCAO at 0.3 and 3 mg/kg

Formal name: 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, monohydrochloride

Synonyms:  SM-346

Molecular weight: 343.9

CAS: 173352-39-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroprotection|Ischemia

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