An inhibitor of staphylococcal FabI (Ki = 12.8 nM); selective for isolates of methicillin-susceptible and methicillin-resistant S. aureus (MIC90s = ≤0.008 μg/ml) over isolates of S. pneumoniae

AFN-1252 – 25 mg

Brand:
Cayman
CAS:
620175-39-5
Storage:
-20
UN-No:
Non-Hazardous - /

AFN-1252 is an inhibitor of staphylococcal enoyl-acyl carrier protein reductase (FabI; Ki = 12.8 nM), an enzyme that activates bacterial fatty acid biosynthesis.{41747,41745,41746} It is selective for isolates of methicillin-susceptible and methicillin-resistant S. aureus (MIC90s = ≤0.008 μg/ml) over isolates of S. pneumoniae, β-hemolytic streptococci, Enterococcus, Enterobacteriaceae, non-fermentative Gram-negative bacilli, and M. catarrhalis (MIC90s = >4 μg/ml). In vivo, AFN-1252 increases survival in a murine acute lethal septicemia model, showing 100% survival when administered at a single oral dose of 1 mg/kg.{41747}  

 

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SKU: 24686 - 25 mg Category:

Description

An inhibitor of staphylococcal FabI (Ki = 12.8 nM); selective for isolates of methicillin-susceptible and methicillin-resistant S. aureus (MIC90s = ≤0.008 μg/ml) over isolates of S. pneumoniae, β-hemolytic streptococci, Enterococcus, Enterobacteriaceae, non-fermentative Gram-negative bacilli, and M. catarrhalis (MIC90s = >4 μg/ml); increases survival in a murine acute lethal septicemia model at 1 mg/kg

Formal name: N-methyl-N-[(3-methyl-2E-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-2-propenamide

Synonyms:  API-1252|Debio 1452

Molecular weight: 375.4

CAS: 620175-39-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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