A genotoxic mycotoxin; induces the formation of DNA adducts in rat liver microsomes; induces transversion of G to T at codon 29 of the p53 tumor suppressor gene in HepG2 cells; induces hepatocellular carcinoma tumor formation in rats at 50 and 100 µg/kg

Aflatoxin B1 – 5 mg

Brand:
Cayman
CAS:
1162-65-8
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Aflatoxin B1 (AFB1) is a genotoxic mycotoxin that has been found in Aspergillus.{52844,20403} It induces the formation of DNA adducts in rat liver microsomes.{52844} AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.{20403} In vivo, AFB1 (50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.{52845}  

 

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SKU: 11293 - 5 mg Category:

Description

A genotoxic mycotoxin; induces the formation of DNA adducts in rat liver microsomes; induces transversion of G to T at codon 29 of the p53 tumor suppressor gene in HepG2 cells; induces hepatocellular carcinoma tumor formation in rats at 50 and 100 µg/kg

Formal name: 2,3,6aR,9aS-tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione

Synonyms:  AFB1|HSDB 3453|NSC 529592

Molecular weight: 312.3

CAS: 1162-65-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer|DNA Damage and Repair||Research Area|Toxicology|Environmental

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