An internal standard for the quantification of afatinib by GC- or LC-MS

Afatinib-d6 – 1 mg

Brand:
Cayman
CAS:
1313874-96-2
Storage:
-20
UN-No:
Non-Hazardous - /

Afatinib-d6 is intended for use as an internal standard for the quantification of afatinib (Item Nos. 21567 | 11492) by GC- or LC-MS. Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively).{33871} It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein.{42401} Afatinib (20 mg/kg) reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models.{42402} Formulations containing afatinib have been used in the treatment of non-small cell lung cancer.  

 

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Description

An internal standard for the quantification of afatinib by GC- or LC-MS

Formal name: (2E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-[di(methyl-d3)amino]-2-butenamide

Synonyms: 

Molecular weight: 492

CAS: 1313874-96-2

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Multidrug Resistance

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