An M2 and M4 muscarinic acetylcholine receptor antagonist (Kis = 6.03 and 10 nM

AF-DX 384 – 1 mg

Brand:
Cayman
CAS:
118290-26-9
Storage:
-20
UN-No:
Non-Hazardous - /

AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively).{42379} It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 µM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg.{42380} It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine (Item No. 14108).  

 

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SKU: 25638 - 1 mg Category:

Description

An M2 and M4 muscarinic acetylcholine receptor antagonist (Kis = 6.03 and 10 nM, respectively); selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively); increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo following local infusion at 1 µM and in the cortex at 5 mg/kg, i.p.; reverses deficits in novel object recognition and passive avoidance in aged rats, as well as scopolamine-induced deficits in young rats

Formal name: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Synonyms: 

Molecular weight: 478.6

CAS: 118290-26-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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